The weapons will base their power on character stats more than a player's aiming skills, being more of an RPG than an FPS in this regard. For example, a player can place points in an Accuracy statistic that determines the randomness of the rounds they fire. The more points into Accuracy you have, the tighter the spread of the bullets will be.

Unlike Diablo II, each weapons type does have a very different effect. For example, the Grizzly Rifle fires a stream of energy that causes splash damage on impact; the Rebounder fires elastic energy balls that ricochet off walls; and the Cabalist-only Locust Hive is a short ranged rifle that causes a swarm of robotic insects to sting and damage the target over time. Melee weapons are less varied, but there are swords that can inflict toxic poison or explode with splash damage on striking.